Cortical cytoskeleton organization

Across TCGA patient cohorts, RNA activity of the Cortical cytoskeleton organization pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C8G, PLEC, and SRRM2_S950, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cortical cytoskeleton organization activity versus C8G in UCEC (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C8G →	+0.772	+0.318	<.001	<.001	3	5
UCEC	PLEC →	+0.404	+0.234	<.001	.001	3	5
BRCA	SRRM2_S950 →	-0.530	-0.183	.001	<.001	3	4
UCEC	RIPOR1 →	+0.274	+0.267	.005	<.001	3	4
UCEC	RPRD2 →	-0.339	-0.218	<.001	.002	3	4
UCEC	ECM1 →	+0.718	+0.260	<.001	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030865 vs C8G — UCEC

Explore this scatter interactively →