Cortical cytoskeleton organization

Across TCGA cell cohorts, RNA activity of the Cortical cytoskeleton organization pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LOXL2, CAST, and PLK2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LOXL2 grouped by Cortical cytoskeleton organization-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	LOXL2 →	+5.146	+0.268	<.001	.001	3	6
LUNG_SCLC	CAST →	+1.685	+0.232	<.001	<.001	3	6
BONE	PLK2 →	+5.240	+0.332	<.001	<.001	3	5
BREAST	RRAS →	+1.232	+0.185	<.001	.001	3	5
BONE	PEA15 →	+2.815	+0.296	<.001	.001	2	6
BONE	KRT80 →	+4.542	+0.313	<.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LOXL2 by Cortical cytoskeleton organization activity — BONE

Explore this box plot interactively →