Cortical cytoskeleton organization

Across TCGA cell cohorts, RNA activity of the Cortical cytoskeleton organization pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC42EP1, PRMT5, and WIPI2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDC42EP1 grouped by Cortical cytoskeleton organization-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CDC42EP1 →	-0.252	-0.087	<.001	.005	3	6
URINARY_TRACT	PRMT5 →	+0.623	+0.080	<.001	<.001	3	5
CNS	WIPI2 →	-0.339	-0.084	.003	.002	3	5
OESOPHAGUS	ANGEL1 →	-0.090	-0.090	.002	.005	3	5
LUNG_NSCLC_LUSC	FGF13 →	+0.320	+0.080	.005	.001	3	5
BREAST	ANAPC5 →	+0.265	+0.076	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDC42EP1 by Cortical cytoskeleton organization activity — BONE

Explore this box plot interactively →