Cortical cytoskeleton organization

Across TCGA cell cohorts, RNA activity of the Cortical cytoskeleton organization pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EHBP1L1, LGALS1, and CYLD, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cortical cytoskeleton organization activity versus EHBP1L1 in SOFT_TISSUE (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	EHBP1L1 →	+2.300	+0.370	.001	.001	3	6
BLOOD_Leukemia	LGALS1 →	+3.102	+0.205	<.001	.002	3	6
SOFT_TISSUE	CYLD →	+1.056	+0.370	<.001	<.001	3	5
SOFT_TISSUE	FADD →	+1.106	+0.446	.004	<.001	3	5
SOFT_TISSUE	FAM20C →	+3.667	+0.315	.009	.003	3	5
STOMACH	ARPC2 →	+0.920	+0.291	.001	.002	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030865 vs EHBP1L1 — SOFT_TISSUE

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