Polarized epithelial cell differentiation

Across TCGA patient cohorts, RNA activity of the Polarized epithelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BMP7, LGALS9, and IL21R-AS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polarized epithelial cell differentiation activity versus BMP7 in LSCC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	BMP7 →	+1.197	+0.713	.002	.002	3	5
OV	LGALS9 →	-0.741	-0.728	.002	.001	3	4
CCRCC	IL21R-AS1 →	-0.192	-0.356	<.001	.008	3	4
UCEC	PLEKHF2 →	+0.386	+0.417	.004	.008	2	5
LSCC	TSSK5P →	+0.605	+0.597	.001	.005	3	4
HNSC	LMOD3 →	-1.009	-0.687	.007	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030859 vs BMP7 — LSCC

Explore this scatter interactively →