Negative regulation of epithelial cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of epithelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AHCY, C19orf48, and H1-2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of epithelial cell differentiation activity versus AHCY in LSCC (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AHCY →	+0.671	+0.830	.002	<.001	3	4
LSCC	C19orf48 →	+0.781	+0.749	<.001	<.001	3	4
BRCA	H1-2 →	+1.130	+0.513	.001	.007	3	4
LSCC	NFE2L2 →	+0.956	+0.909	<.001	<.001	3	4
HNSC	RFC4 →	+0.971	+0.605	<.001	.001	3	4
LSCC	ZNF3 →	+0.595	+0.812	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030857 vs AHCY — LSCC

Explore this scatter interactively →