Positive regulation of granulocyte differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of granulocyte differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIB1, LEF1, and THBS2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRIB1 grouped by Positive regulation of granulocyte differentiation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TRIB1 →	-0.249	-0.747	.001	.001	3	7
LARGE_INTESTINE	LEF1 →	-0.269	-0.772	.002	.007	3	5
KIDNEY	THBS2 →	-0.142	-0.797	.003	.007	3	4
PANCREAS	KLF15 →	-0.098	-0.758	.001	.003	3	4
BLOOD_Lymphoma	C5orf15 →	-0.410	-1.615	.007	.004	2	4
BLOOD_Lymphoma	UGT2B4 →	+0.375	+1.665	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRIB1 by Positive regulation of granulocyte differentiation activity — BLOOD_Leukemia

Explore this box plot interactively →