Positive regulation of granulocyte differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of granulocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLOD1, SAP30BP, and ATP6V1G2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of granulocyte differentiation activity versus PLOD1 in LUNG_NSCLC_LUAD (Pearson r = -0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PLOD1 →	-1.289	-1.824	.005	<.001	3	4
LUNG_NSCLC_LUAD	SAP30BP →	-1.066	-1.747	.005	<.001	2	4
BLOOD_Leukemia	ATP6V1G2 →	+1.234	+0.470	<.001	.003	3	3
BLOOD_Leukemia	FHL1 →	+2.193	+0.500	<.001	.003	3	3
BLOOD_Leukemia	PRAF2 →	+1.234	+0.554	.003	.002	3	3
STOMACH	ZNF287 →	+1.685	+1.575	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030854 vs PLOD1 — LUNG_NSCLC_LUAD

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