Negative regulation of granulocyte differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of granulocyte differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MKI67, CDK1, and GRAP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of granulocyte differentiation activity versus MKI67 in COAD (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MKI67 →	-0.595	-0.059	<.001	<.001	3	7
CCRCC	CDK1 →	-0.347	-0.040	.003	.001	3	6
UCEC	GRAP →	+0.408	+0.078	.001	<.001	3	6
GBM	MCM4 →	-0.663	-0.047	<.001	.006	3	6
LSCC	MCM7 →	-0.458	-0.073	<.001	<.001	3	6
LSCC	NUP88_S517 →	-0.543	-0.080	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030853 vs MKI67 — COAD

Explore this scatter interactively →