Granulocyte differentiation

Across TCGA patient cohorts, RNA activity of the Granulocyte differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SVIL_T657, GIMAP4, and LSP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Granulocyte differentiation activity versus SVIL_T657 in GBM (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SVIL_T657 →	+0.939	+0.074	<.001	<.001	3	6
LSCC	GIMAP4 →	+0.531	+0.044	<.001	.001	3	6
GBM	LSP1 →	+0.607	+0.047	<.001	<.001	3	6
GBM	APBB1IP →	+0.630	+0.077	<.001	<.001	3	6
GBM	SNX9 →	+0.299	+0.067	<.001	<.001	3	6
GBM	MCM2 →	-0.784	-0.073	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030851 vs SVIL_T657 — GBM

Explore this scatter interactively →