Granulocyte differentiation

Across TCGA cell cohorts, RNA activity of the Granulocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MED7, RCC1, and FASN, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Granulocyte differentiation activity versus MED7 in BLOOD_Myeloma (Pearson r = -0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MED7 →	-0.511	-0.134	.008	.009	3	10
KIDNEY	RCC1 →	+0.782	+0.153	.003	.006	3	9
LARGE_INTESTINE	FASN →	+0.921	+0.109	<.001	<.001	3	8
LARGE_INTESTINE	JAGN1 →	+0.562	+0.105	<.001	<.001	3	8
BONE	PLXNB3 →	-2.000	-0.149	.001	<.001	3	8
LUNG_NSCLC_LUSC	POLR3K →	+0.718	+0.139	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030851 vs MED7 — BLOOD_Myeloma

Explore this scatter interactively →