Prostate gland development

Across TCGA cell cohorts, RNA activity of the Prostate gland development pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRIP1, AFAP1L1, and HOXA1, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Prostate gland development activity versus CRIP1 in BREAST (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CRIP1 →	+5.234	+0.265	<.001	<.001	3	14
OVARY	AFAP1L1 →	-1.729	-0.201	.003	.002	3	7
BONE	HOXA1 →	-1.154	-0.188	<.001	<.001	3	7
STOMACH	IRF2BP2 →	+1.130	+0.124	<.001	.002	3	6
BLOOD_Leukemia	PSMG1 →	-0.707	-0.113	<.001	.004	3	6
BLOOD_Myeloma	PVR →	-2.346	-0.108	.002	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030850 vs CRIP1 — BREAST

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