Positive regulation of actin filament polymerization

Across TCGA patient cohorts, RNA activity of the Positive regulation of actin filament polymerization pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAPCD2, MYBL2, and FAM83D, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of actin filament polymerization activity versus SAPCD2 in GBM (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SAPCD2 →	-1.326	-0.249	<.001	<.001	3	6
GBM	MYBL2 →	-1.439	-0.188	<.001	<.001	3	5
GBM	FAM83D →	-1.295	-0.209	<.001	<.001	3	5
LUAD	LMNB1 →	-0.757	-0.224	<.001	<.001	3	5
LSCC	CENPF →	-1.292	-0.490	<.001	<.001	3	5
LUAD	CNRIP1 →	+0.430	+0.253	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030838 vs SAPCD2 — GBM

Explore this scatter interactively →