Regulation of actin filament length

Across TCGA patient cohorts, RNA activity of the Regulation of actin filament length pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TLN1, TNS2_S120, and CNRIP1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of actin filament length activity versus TLN1 in COAD (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TLN1 →	+0.340	+0.032	<.001	<.001	3	10
HNSC	TNS2_S120 →	+0.617	+0.087	<.001	<.001	3	10
BRCA	CNRIP1 →	+0.633	+0.032	<.001	<.001	3	10
GBM	F13A1 →	+0.645	+0.034	<.001	<.001	3	10
UCEC	PPM1F →	+0.240	+0.048	<.001	<.001	3	10
OV	PRKG1 →	+0.673	+0.045	.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030832 vs TLN1 — COAD

Explore this scatter interactively →