Regulation of actin filament length

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of actin filament length pathway differs between tumor and matched normal tissue in 13 of the 18 cancer types tested.

The strongest signal is observed in colon adenocarcinoma (COAD), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as COAD and LUAD, show the opposite pattern, with lower activity in tumor tissue.

COAD, LUAD, and LUSC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
COAD	Male	All	−0.040	<.001	10	view →
LUAD	Female	III,IV	−0.064	<.001	9	view →
LUSC	Male	III,IV	−0.092	<.001	8	view →
BLCA	All	All	−0.039	<.001	8	view →
KICH	All	II,III,IV	−0.037	<.001	7	view →
BRCA	All	III,IV	−0.056	<.001	6	view →
UCEC	All	All	−0.038	<.001	6	view →
KIRC	All	All	+0.014	<.001	3	view →
READ	All	All	−0.043	.023	2	view →
THCA	All	IV	+0.034	.021	2	view →
HNSC	Female	III,IV	+0.028	.036	2	view →
THCA	Female	All	−0.017	.023	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 13 lineages.

GO:0030832–COAD

Open the COAD breakdown →