Regulation of actin filament length

Across TCGA cell cohorts, RNA activity of the Regulation of actin filament length pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDRG2, MMP19, and ANKRD28, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NDRG2 grouped by Regulation of actin filament length-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	NDRG2 →	+3.491	+0.245	<.001	<.001	3	5
LIVER	MMP19 →	-1.315	-0.158	.006	.005	3	4
LUNG_SCLC	ANKRD28 →	-1.278	-1.387	.002	<.001	3	4
LUNG_NSCLC_LUAD	CDH26 →	+0.489	+0.681	.002	.004	2	4
LUNG_NSCLC_LUAD	SP110 →	+1.203	+0.870	<.001	<.001	3	3
CNS	DESI2 →	+0.469	+0.772	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NDRG2 by Regulation of actin filament length activity — LIVER

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