Regulation of actin filament length

Across TCGA cell cohorts, RNA activity of the Regulation of actin filament length pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLD4, CAP1, and ZMAT5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of actin filament length activity versus POLD4 in BONE (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	POLD4 →	+1.415	+0.262	.004	.009	3	7
BLOOD_Leukemia	CAP1 →	+0.718	+0.173	.001	<.001	3	6
OVARY	ZMAT5 →	+0.664	+0.227	<.001	<.001	3	5
BONE	SLC16A3 →	+4.882	+0.313	.001	.009	2	6
SOFT_TISSUE	WDR1 →	+0.803	+0.283	.004	.001	3	5
LARGE_INTESTINE	CIAO2B →	+0.489	+0.127	.008	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030832 vs POLD4 — BONE

Explore this scatter interactively →