Sequestering of triglyceride

pathway activity — cross-omics
GO:0030730Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Sequestering of triglyceride pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RSU1, DAB2, and ACSL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCRSU1 →+0.290+0.053<.001<.00136
LSCCDAB2 →+0.286+0.041<.001<.00136
OVACSL1 →+0.385+0.037.001<.00136
HNSCRAB3IL1_S179 →+0.432+0.050.007.00936
OVPNN →-0.250-0.042<.001<.00136
LSCCMSN →+0.324+0.046<.001.00136
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration