Germ-line stem cell population maintenance

Across TCGA patient cohorts, RNA activity of the Germ-line stem cell population maintenance pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CHDH, LRRC25, and MRPL16, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Germ-line stem cell population maintenance activity versus CHDH in PDAC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CHDH →	+0.441	+0.736	<.001	.006	3	4
PDAC	LRRC25 →	-0.412	-0.958	.002	<.001	3	4
COAD	MRPL16 →	+0.216	+0.194	<.001	.003	3	4
BRCA	SPN_S355 →	-0.726	-0.580	.001	.004	2	5
BRCA	ZC3HAV1 →	-0.151	-0.580	<.001	<.001	3	4
BRCA	CXorf38 →	-0.259	-0.587	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030718 vs CHDH — PDAC

Explore this scatter interactively →