Germ-line stem cell population maintenance

Across TCGA pan-cancer cohorts, RNA activity of the Germ-line stem cell population maintenance pathway differs between tumor and matched normal tissue in 12 of the 18 cancer types tested.

The strongest signal is observed in breast invasive carcinoma (BRCA), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as BRCA and THCA, show the opposite pattern, with lower activity in tumor tissue.

BRCA, THCA, and BLCA show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
BRCA	All	IV	−1.855	<.001	8	view →
THCA	Male	III,IV	−1.311	<.001	8	view →
BLCA	Male	IV	−1.790	<.001	7	view →
LUAD	All	IV	+1.734	.001	6	view →
UCEC	All	II,III,IV	−1.227	<.001	6	view →
READ	All	III,IV	−0.125	.007	5	view →
CHOL	All	II,III,IV	−1.710	<.001	4	view →
HNSC	All	All	−0.410	.024	3	view →
PRAD	All	All	−0.322	.036	2	view →
KIRP	All	III,IV	+0.592	.044	1	view →
LUSC	All	All	+0.251	.038	1	view →
LIHC	All	All	−0.146	.033	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 12 lineages.

GO:0030718–BRCA

Open the BRCA breakdown →