Cytoskeleton-dependent intracellular transport

Across TCGA cell cohorts, RNA activity of the Cytoskeleton-dependent intracellular transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSE1, VAMP5, and RND3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GSE1 grouped by Cytoskeleton-dependent intracellular transport-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GSE1 →	-2.565	-0.108	<.001	.007	3	5
OESOPHAGUS	VAMP5 →	+2.198	+0.156	.001	<.001	3	4
BREAST	RND3 →	+1.649	+0.110	.003	<.001	3	4
LUNG_SCLC	TNFRSF10B →	+3.589	+0.214	.002	<.001	3	4
STOMACH	PARVA →	+1.604	+0.227	.001	.001	3	4
STOMACH	SEMA7A →	+2.636	+0.218	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GSE1 by Cytoskeleton-dependent intracellular transport activity — BLOOD_Lymphoma

Explore this box plot interactively →