Polyketide metabolic process

Across TCGA patient cohorts, RNA activity of the Polyketide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKR1C2, AKR1C3, and AKR1C1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polyketide metabolic process activity versus AKR1C2 in LSCC (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AKR1C2 →	+3.294	+0.211	<.001	<.001	3	9
LSCC	AKR1C3 →	+2.333	+0.156	<.001	<.001	3	9
LSCC	AKR1C1 →	+2.594	+0.169	<.001	<.001	3	8
LSCC	AKR1B10 →	+3.857	+0.173	<.001	<.001	3	6
GBM	ALDH1A1 →	+0.936	+0.136	<.001	<.001	3	6
BRCA	MAOA →	+1.187	+0.226	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030638 vs AKR1C2 — LSCC

Explore this scatter interactively →