Nuclear body organization

Across TCGA patient cohorts, RNA activity of the Nuclear body organization pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COLGALT1, TGFBI, and PELATON, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear body organization activity versus COLGALT1 in LUAD (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	COLGALT1 →	+0.409	+0.146	.007	.005	3	5
PDAC	TGFBI →	+0.606	+0.089	<.001	.007	3	4
PDAC	PELATON →	+0.565	+0.131	.002	.005	3	4
LUAD	CD46 →	-0.493	-0.201	<.001	<.001	3	3
LUAD	ADAM12 →	+0.704	+0.166	.006	.002	3	3
GBM	ARHGAP12 →	-0.382	-0.191	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030575 vs COLGALT1 — LUAD

Explore this scatter interactively →