Nuclear body organization

Across TCGA patient cohorts, RNA activity of the Nuclear body organization pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UHRF1BP1_S922, SAMD9, and UQCRB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear body organization activity versus UHRF1BP1_S922 in UCEC (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UHRF1BP1_S922 →	+0.501	+0.244	<.001	<.001	3	4
HNSC	SAMD9 →	+0.468	+0.230	<.001	<.001	3	3
GBM	UQCRB →	-0.463	-0.231	<.001	<.001	3	3
GBM	UQCRC2 →	-0.395	-0.222	<.001	<.001	3	3
LSCC	ZNF532_S298 →	+0.511	+0.131	<.001	<.001	3	3
LSCC	ZNF768_S125 →	-0.532	-0.134	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030575 vs UHRF1BP1_S922 — UCEC

Explore this scatter interactively →