Collagen catabolic process

Across TCGA cell cohorts, RNA activity of the Collagen catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GALM, ABHD14A, and TERF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GALM grouped by Collagen catabolic process-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GALM →	+2.278	+1.445	.002	<.001	3	5
KIDNEY	ABHD14A →	+0.924	+1.075	.007	.009	2	5
BLOOD_Myeloma	TERF1 →	+1.041	+1.488	.003	.006	2	5
BONE	DPEP1 →	+2.004	+1.572	<.001	.001	3	4
OVARY	PLEK2 →	-2.611	-1.134	.001	.001	3	4
LARGE_INTESTINE	GRHL1 →	+1.267	+1.277	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GALM by Collagen catabolic process activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →