Female genitalia development

Across TCGA patient cohorts, RNA activity of the Female genitalia development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IKZF1_S63, LTBP4, and ARHGEF40, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Female genitalia development activity versus IKZF1_S63 in LSCC (Pearson r = 0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IKZF1_S63 →	-0.595	-0.045	.002	.002	3	6
OV	LTBP4 →	+0.603	+0.043	.007	.008	3	5
LUAD	ARHGEF40 →	+0.289	+0.047	<.001	.001	3	5
BRCA	CCN3 →	+0.724	+0.033	<.001	.001	3	5
GBM	DNPH1_S123 →	-0.685	-0.120	.003	.005	3	5
LUAD	MAP1B_S91 →	+0.432	+0.027	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030540 vs IKZF1_S63 — LSCC

Explore this scatter interactively →