Male genitalia development

Across TCGA patient cohorts, RNA activity of the Male genitalia development pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THEMIS2, AR, and MMP11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Male genitalia development activity versus THEMIS2 in OV (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	THEMIS2 →	-0.578	-0.557	.008	.001	2	5
BRCA	AR →	+1.914	+0.352	<.001	<.001	3	4
BRCA	MMP11 →	+1.369	+0.362	<.001	.001	3	4
BRCA	HTR7P1 →	+1.047	+0.603	<.001	<.001	3	4
BRCA	PRDM6 →	+0.534	+0.381	<.001	.002	3	4
LSCC	CFAP69 →	+0.342	+0.432	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030539 vs THEMIS2 — OV

Explore this scatter interactively →