Male genitalia development

Across TCGA cell cohorts, RNA activity of the Male genitalia development pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NXPE3, BARX2, and IGFBP5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NXPE3 grouped by Male genitalia development-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NXPE3 →	-0.146	-0.854	<.001	.002	3	4
KIDNEY	BARX2 →	-0.279	-1.261	<.001	<.001	3	3
OESOPHAGUS	IGFBP5 →	+0.138	+1.067	.005	.002	3	3
UPPER_AERODIGESTIVE_TRACT	CACNG2 →	+0.146	+1.424	.001	.002	3	3
SKIN	FBXW7 →	-0.229	-0.837	.002	.006	3	3
LUNG_NSCLC_LUAD	RASL12 →	+0.090	+0.521	.004	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NXPE3 by Male genitalia development activity — BREAST

Explore this box plot interactively →