Intracellular estrogen receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Intracellular estrogen receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PNN, PRPF40B, and NKTR, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular estrogen receptor signaling pathway activity versus PNN in UVM (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	PNN →	+1.570	+0.046	<.001	<.001	3	34
THYM	PRPF40B →	+1.211	+0.065	<.001	<.001	3	34
DLBC	NKTR →	+1.808	+0.080	<.001	<.001	3	34
UVM	INO80D →	+1.065	+0.046	<.001	<.001	3	34
DLBC	KANSL3 →	+0.674	+0.055	<.001	<.001	3	34
DLBC	PIKFYVE →	+1.552	+0.058	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030520 vs PNN — UVM

Explore this scatter interactively →