Intracellular estrogen receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Intracellular estrogen receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CBX1, ADNP, and LUC7L3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular estrogen receptor signaling pathway activity versus CBX1 in HNSC (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CBX1 →	+0.414	+0.074	<.001	.002	3	5
LUAD	ADNP →	+0.190	+0.042	<.001	.001	3	5
UCEC	LUC7L3 →	+0.169	+0.056	.001	.004	3	5
LSCC	MICALL1 →	-0.452	-0.045	<.001	<.001	3	5
UCEC	MED28 →	+0.135	+0.052	.007	.001	3	5
BRCA	MAGED2_T72 →	+0.612	+0.041	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030520 vs CBX1 — HNSC

Explore this scatter interactively →