Intracellular estrogen receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Intracellular estrogen receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CCAR1, SAFB2, and SMARCD2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular estrogen receptor signaling pathway activity versus CCAR1 in CCRCC (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CCAR1 →	+0.193	+0.160	<.001	<.001	3	6
LSCC	SAFB2 →	+0.185	+0.141	<.001	<.001	3	5
HNSC	SMARCD2 →	+0.225	+0.167	<.001	<.001	3	5
GBM	THRAP3 →	+0.282	+0.167	<.001	<.001	3	5
LSCC	TRIR →	+0.304	+0.131	<.001	<.001	3	5
LSCC	CHERP →	+0.224	+0.127	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030520 vs CCAR1 — CCRCC

Explore this scatter interactively →