Intracellular estrogen receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Intracellular estrogen receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CALML6, ORMDL3, and PAPPA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CALML6 grouped by Intracellular estrogen receptor signaling pathway-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CALML6 →	+0.424	+0.299	.001	.003	3	4
OVARY	ORMDL3 →	-0.689	-0.253	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	PAPPA →	+1.626	+0.275	.002	.002	3	3
BREAST	GNG13 →	+0.884	+0.210	.001	.009	3	3
BREAST	GNAZ →	+1.429	+0.289	<.001	<.001	3	3
BREAST	HSD17B12 →	-0.992	-0.245	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CALML6 by Intracellular estrogen receptor signaling pathway activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →