Intracellular estrogen receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Intracellular estrogen receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBTD1, AXL, and FLII, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular estrogen receptor signaling pathway activity versus UBTD1 in BONE (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	UBTD1 →	+1.847	+0.150	<.001	<.001	3	10
BONE	AXL →	+4.504	+0.123	<.001	.001	3	10
BONE	FLII →	+1.338	+0.137	<.001	<.001	2	11
LUNG_NSCLC_LUSC	TADA3 →	+0.980	+0.096	.008	.006	1	11
BONE	PDLIM7 →	+1.862	+0.109	.001	.001	2	10
SKIN	TMEM43 →	+0.779	+0.098	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030520 vs UBTD1 — BONE

Explore this scatter interactively →