Positive regulation of BMP signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of BMP signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USP34, MBTD1, and ZBTB1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of BMP signaling pathway activity versus USP34 in BRCA (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	USP34 →	+0.621	+0.871	.001	<.001	3	6
BRCA	MBTD1 →	+0.513	+0.707	.003	.001	3	5
BRCA	ZBTB1 →	+0.529	+0.859	.002	.001	3	5
BRCA	SIN3A →	+0.360	+0.497	<.001	.005	3	5
BRCA	NF1 →	+0.507	+0.677	.005	.009	3	5
COAD	NRDE2 →	+0.314	+0.706	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030513 vs USP34 — BRCA

Explore this scatter interactively →