Negative regulation of transforming growth factor beta receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of transforming growth factor beta receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PABPC1L, CLK3, and CDT1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of transforming growth factor beta receptor signaling pathway activity versus PABPC1L in GBM (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PABPC1L →	+0.790	+0.286	<.001	.002	3	4
OV	CLK3 →	+0.513	+0.307	<.001	<.001	3	4
BRCA	CDT1 →	+0.797	+0.142	.001	.002	3	4
OV	ZNF581 →	+0.823	+0.275	.002	.003	3	4
BRCA	TRMT1 →	+0.765	+0.151	<.001	.003	3	3
UCEC	NFKBID →	+0.401	+0.166	.008	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030512 vs PABPC1L — GBM

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