Regulation of bone mineralization

Across TCGA patient cohorts, RNA activity of the Regulation of bone mineralization pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SGCD, RSU1, and SEPTIN2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of bone mineralization activity versus SGCD in GBM (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SGCD →	+0.797	+0.060	<.001	<.001	3	10
UCEC	RSU1 →	+0.421	+0.043	<.001	<.001	3	10
OV	SEPTIN2 →	+0.283	+0.077	<.001	<.001	3	10
UCEC	SORBS1 →	+0.845	+0.057	<.001	<.001	3	10
OV	SVIL_T657 →	+1.006	+0.043	<.001	<.001	3	10
HNSC	SYNPO2 →	+0.757	+0.034	<.001	.004	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030500 vs SGCD — GBM

Explore this scatter interactively →