Regulation of bone mineralization

Across TCGA cell cohorts, RNA activity of the Regulation of bone mineralization pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FLVCR1, LRFN1, and USP12, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of bone mineralization activity versus FLVCR1 in PANCREAS (Pearson r = -0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	FLVCR1 →	-0.885	-0.955	<.001	.007	3	5
BLOOD_Lymphoma	LRFN1 →	-0.802	-0.463	.001	.001	3	5
BLOOD_Myeloma	USP12 →	-0.948	-0.513	.001	.007	3	4
BREAST	ME3 →	+1.830	+1.067	<.001	.001	3	4
URINARY_TRACT	CREB3L1 →	+3.744	+1.459	.005	.002	3	4
URINARY_TRACT	PDCD1LG2 →	+2.158	+1.683	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030500 vs FLVCR1 — PANCREAS

Explore this scatter interactively →