Fatty acid elongation

Across TCGA patient cohorts, RNA activity of the Fatty acid elongation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PNPLA3, CKAP2L, and JPT1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid elongation activity versus PNPLA3 in LSCC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PNPLA3 →	+0.891	+0.158	<.001	.005	3	3
LSCC	CKAP2L →	+0.421	+0.160	.003	<.001	3	3
LSCC	JPT1 →	+0.598	+0.145	<.001	.004	3	3
LSCC	SNED1-AS1 →	-0.581	-0.140	<.001	.005	3	3
HNSC	PCDHGA7 →	-0.710	-0.208	.003	<.001	3	3
LUAD	MIR4499 →	+0.626	+0.131	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030497 vs PNPLA3 — LSCC

Explore this scatter interactively →