Nuclear migration along microtubule

Across TCGA patient cohorts, RNA activity of the Nuclear migration along microtubule pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN7, STAG1, and CHD4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear migration along microtubule activity versus SEPTIN7 in CCRCC (Pearson r = 0.53).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SEPTIN7 →	+0.203	+0.053	<.001	<.001	3	5
BRCA	STAG1 →	+0.282	+0.051	.002	.002	3	5
BRCA	CHD4 →	+0.297	+0.066	<.001	<.001	3	5
BRCA	PLEKHG3_S617 →	+0.830	+0.053	.002	.008	3	5
LUAD	ZC3HC1_S24 →	-0.754	-0.056	<.001	<.001	3	5
CCRCC	CRIP2 →	+0.390	+0.050	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030473 vs SEPTIN7 — CCRCC

Explore this scatter interactively →