Nuclear migration along microtubule

Across TCGA patient cohorts, RNA activity of the Nuclear migration along microtubule pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C20orf96, RN7SKP269, and RPL10P6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear migration along microtubule activity versus C20orf96 in BRCA (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	C20orf96 →	-0.737	-0.597	.004	.001	3	4
UCEC	RN7SKP269 →	+1.153	+0.325	.001	.005	3	4
UCEC	RPL10P6 →	+1.295	+0.254	.006	.004	3	4
LUAD	OGG1 →	+0.244	+0.516	.002	.005	3	3
LUAD	TMF1 →	+0.269	+0.591	.001	.007	3	3
LUAD	IFT122 →	+0.305	+0.581	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030473 vs C20orf96 — BRCA

Explore this scatter interactively →