Nuclear migration along microtubule

Across TCGA cell cohorts, RNA activity of the Nuclear migration along microtubule pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFSF8, MED1, and DDX54, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TNFSF8 grouped by Nuclear migration along microtubule-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TNFSF8 →	-0.253	-0.116	.009	.002	3	5
STOMACH	MED1 →	-0.738	-0.121	<.001	.001	3	5
OVARY	DDX54 →	-0.207	-0.086	.001	<.001	3	4
URINARY_TRACT	ACKR4 →	+0.205	+0.153	<.001	<.001	3	4
SOFT_TISSUE	MYLK →	-0.198	-0.120	<.001	.002	3	4
PANCREAS	IL15RA →	-0.229	-0.137	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TNFSF8 by Nuclear migration along microtubule activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →