"Regulation of complement activation, alternative pathway"

Across TCGA patient cohorts, RNA activity of the "Regulation of complement activation, alternative pathway" pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MSN, JCAD_S755, and ENTPD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of complement activation, alternative pathway" activity versus MSN in COAD (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MSN →	+0.327	+0.064	.005	.001	3	6
PDAC	JCAD_S755 →	+0.729	+0.048	<.001	<.001	3	6
CCRCC	ENTPD1 →	+0.363	+0.107	<.001	.003	3	6
UCEC	STAB1 →	+0.285	+0.102	.004	.004	3	6
PDAC	VSIG4 →	+0.510	+0.054	<.001	<.001	3	5
LSCC	AHNAK_S2836 →	+0.474	+0.093	.005	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030451 vs MSN — COAD

Explore this scatter interactively →