"Regulation of complement activation, alternative pathway"

Across TCGA patient cohorts, RNA activity of the "Regulation of complement activation, alternative pathway" pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRYBB1, SLC2A5, and VSIG4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of complement activation, alternative pathway" activity versus CRYBB1 in GBM (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CRYBB1 →	+0.720	+0.166	<.001	.002	3	5
GBM	SLC2A5 →	+0.917	+0.240	<.001	.001	3	5
GBM	VSIG4 →	+0.962	+0.250	<.001	<.001	3	5
GBM	ADAP2 →	+0.688	+0.193	<.001	<.001	3	5
GBM	TMEM106A →	+0.319	+0.198	.004	.003	3	5
GBM	MAFB →	+1.181	+0.209	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030451 vs CRYBB1 — GBM

Explore this scatter interactively →