"Regulation of complement activation, alternative pathway"

Across TCGA cell cohorts, RNA activity of the "Regulation of complement activation, alternative pathway" pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GINM1, PDE4A, and ZNF721, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GINM1 grouped by "Regulation of complement activation, alternative pathway"-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GINM1 →	-1.068	-1.173	.003	<.001	3	4
SOFT_TISSUE	PDE4A →	-1.611	-0.777	.002	.007	3	4
LARGE_INTESTINE	ZNF721 →	+0.643	+0.754	.007	.001	3	4
BLOOD_Myeloma	VPS54 →	-0.864	-1.637	.001	.003	3	3
BLOOD_Myeloma	TMEM230 →	-0.796	-1.660	.008	.001	3	3
BLOOD_Lymphoma	TMEM86A →	+0.717	+1.787	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GINM1 by "Regulation of complement activation, alternative pathway" activity — OESOPHAGUS

Explore this box plot interactively →