"Regulation of complement activation, alternative pathway"

Across TCGA cell cohorts, RNA activity of the "Regulation of complement activation, alternative pathway" pathway is significantly associated with the protein abundance of multiple proteins, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PCNP, UBE2N, and PSMB6, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of complement activation, alternative pathway" activity versus PCNP in BREAST (Pearson r = -0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PCNP →	-0.905	-1.370	.005	<.001	3	7
PANCREAS	UBE2N →	-1.698	-1.662	<.001	<.001	3	7
PANCREAS	PSMB6 →	-1.322	-1.833	<.001	<.001	3	7
BLOOD_Lymphoma	GALNT2 →	+1.802	+1.327	.005	.009	2	7
PANCREAS	GDI2 →	-1.699	-1.501	<.001	<.001	3	6
PANCREAS	EIF4B →	-1.755	-1.537	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030451 vs PCNP — BREAST

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