"Regulation of complement activation, classical pathway"

Across TCGA patient cohorts, RNA activity of the "Regulation of complement activation, classical pathway" pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CHAF1B_S429, ASAH1, and AGO1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of complement activation, classical pathway" activity versus CHAF1B_S429 in LUAD (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CHAF1B_S429 →	-0.609	-0.100	.003	<.001	3	5
UCEC	ASAH1 →	+0.405	+0.080	.001	.002	3	5
UCEC	AGO1 →	+0.225	+0.055	<.001	.009	3	5
HNSC	RASGRP2 →	-0.323	-0.116	.003	<.001	3	5
LUAD	SIAE →	+0.350	+0.053	.006	.005	3	5
GBM	MRC1 →	-0.639	-0.082	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030450 vs CHAF1B_S429 — LUAD

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