"Regulation of complement activation, classical pathway"

Across TCGA patient cohorts, RNA activity of the "Regulation of complement activation, classical pathway" pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBLN5, CYP1B1, and SRPX, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of complement activation, classical pathway" activity versus FBLN5 in OV (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FBLN5 →	+1.227	+0.137	<.001	.002	3	7
OV	CYP1B1 →	+1.568	+0.223	<.001	<.001	3	7
BRCA	SRPX →	+1.700	+0.274	<.001	<.001	3	6
BRCA	CXCL12 →	+1.486	+0.240	<.001	<.001	3	6
LSCC	C7 →	+1.612	+0.199	<.001	<.001	3	6
OV	PTH1R →	+0.953	+0.189	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030450 vs FBLN5 — OV

Explore this scatter interactively →