"Regulation of complement activation, classical pathway"

Across TCGA cell cohorts, RNA activity of the "Regulation of complement activation, classical pathway" pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOP56, ITPA, and PEX19, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NOP56 grouped by "Regulation of complement activation, classical pathway"-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NOP56 →	-0.696	-0.823	.002	.005	2	5
BREAST	ITPA →	-1.030	-0.847	.004	.003	2	4
LUNG_NSCLC_LUAD	PEX19 →	+0.405	+0.576	.007	.008	3	3
STOMACH	ELK3 →	-1.484	-1.114	<.001	.002	3	3
STOMACH	APOOL →	+1.059	+1.129	.005	.001	3	3
URINARY_TRACT	DCAF4 →	-2.079	-0.551	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NOP56 by "Regulation of complement activation, classical pathway" activity — BREAST

Explore this box plot interactively →