siRNA processing

Across TCGA cell cohorts, RNA activity of the siRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OMP, TRIM31, and SCPEP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OMP grouped by siRNA processing-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OMP →	+0.305	+1.146	.003	.001	3	5
STOMACH	TRIM31 →	+2.488	+0.924	.006	.002	1	6
LUNG_NSCLC_LUAD	SCPEP1 →	+0.805	+1.138	.008	<.001	3	4
OVARY	RHBDL2 →	+2.000	+1.030	.001	.003	3	3
OVARY	CYC1 →	-0.792	-1.050	.003	.002	3	3
OVARY	ALDH3B1 →	+2.205	+1.293	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OMP by siRNA processing activity — CNS

Explore this box plot interactively →