Membrane disassembly

Across TCGA patient cohorts, RNA activity of the Membrane disassembly pathway is significantly associated with the RNA expression of multiple genes, with the ACC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FANCD2, LPIN1, and BRCA2, each associated with the pathway in up to 26 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane disassembly activity versus FANCD2 in ACC (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	FANCD2 →	+0.980	+0.056	<.001	<.001	3	26
LAML	LPIN1 →	+0.957	+0.075	<.001	<.001	3	25
ACC	BRCA2 →	+0.684	+0.060	<.001	<.001	3	25
UVM	ATAD5 →	+0.775	+0.049	<.001	<.001	2	26
UVM	KNTC1 →	+1.156	+0.046	<.001	<.001	3	25
UVM	BRCA1 →	+0.947	+0.048	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030397 vs FANCD2 — ACC

Explore this scatter interactively →